For Illustrative Purpose Only |
ON October 3,
the Nobel Assembly at Karolinska Institute awarded
the Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discovery of mechanisms for autophagy. The
word auto means self and phagein means to eat, essentially self-eating.
The human body is
made up of billions of cells. And each cell has certain components including
the nuclei, various organelles, proteins and cell membranes and walls. Over
time the overall cell might be good but certain components of it may not
work at hundred percent. Just like in a car, sometimes the batteries fail or
the tires wear out. In such times you service the car and replace
the battery or change the tires. Similarly at a cellular level the body
identifies such broken audience or cell components and actually does its own
servicing.
For a car it’s a
mechanic, but for your body it is a highly specialized organelle containing
enzymes that degrades proteins called as a lysosome. This lysosome will
actually convert the dead components into cell waste and send it for recycling.
The cell makes a new component with the nutrients supplied to it by the blood.
It’s a beautiful
system, whatever is old and useless is removed and a chance is given for the new to
grow and regenerate. It seems that some how your own body treats
those components which are no longer working fine. But that is what life is. A
philosophical outlook towards autophagy may be the best outlook. Autophagy
actually ensures that you have a healthy and essentially a younger body at
cellular level without redundant components. It is the body’s healing touch for
itself.
Now we come to a
question, What kicks off autophagy? Research shows that it is a hormone called
glucagon. When the level of glucagon goes up in the body the body starts to
kick off the autoclean cycle. Autophagy is activated and cell damage is
repaired. What is the key driver of glucagon production? It is nutrient deprivation. In
simple terms, fasting!! Depriving your body of essential nutrients actually can ensure that autophagy can take place. The best way to do it is intermittent fasting.
Fasting actually has the dual effect of autophagy and of stimulating the growth
hormone. You are not only getting rid of the old parts but also ensuring the
body makes some new ones! There cannot be a better deal than this.
The beneficial
effects of fasting was surely a part of the ancient knowledge, that not only Indians but all civilizations understood it in some form or the other. All
religions have got fasting as a feature of the religious beliefs and tenants.
Islam has the month of Ramadan in which the devout are encouraged to fast from
dawn to dusk. Christianity also has fasting days and days of renunciation.
Fasts are kept on certain days like on the birthdays of saints and feasts happen
after the midnight mass. Fasts in these religions are not only an obligation.
It is also regarded as a means of getting closer to god and being more
spiritual.
The most abundant
use of fasting would be in Hindu traditions. In earlier times fasts are common, people used to pick a day of the week and fast. Additionally, there were
fasts on various religious occasions. Every 11th day of the lunar
calendar was also considered to be a good day for fasting. Fasting in Sanskrit
is called upavaasa. Upa means “near” and vaasa means “to stay”. Upavaasa
therefore means staying near (the Lord), meaning the attainment of close mental
proximity with the Lord. The theory as per ancient texts being that deprivation
of the nutrients has a beneficial effect on digestion as well as gives more
time for contemplation of God.
Unfortunately, all
fasts in modern days have left their ancient roots and have become mere
rituals. From the eating heaps of food that is permitted during fasting like
sago and fruits, to the meat and oil laden feats at sunset and midnight after
the days fasts. All religions, have lost the spiritual component at a certain
level.
Perhaps it is
instructive to read this verse from the Bhagwat Gita, one of the key religious
texts of Hinduism.
नात्यश्नतस्तुयोगोऽस्तिनचैकान्तमनश्नत: |
नचातिस्वप्नशीलस्यजाग्रतोनैवचार्जुन ||
नचातिस्वप्नशीलस्यजाग्रतोनैवचार्जुन ||
The meaning is “O
Arjuna, the science of uniting ones consciousness with that of the supreme
consciousness is not for one who eats too much or for one who eats too little
or for one who sleeps too little or one who sleeps too much.
Moderation is the
key. What this years Nobel prize has done is that it has shine a
light on the benefits of fasting and re-validated the ancient wisdom of the
ages.
Sadly, the most
ancient wisdom of the Indian subcontinent, may be lost to us forever. The
ancient secret sciences that were hidden from humanity for its own benefit
may have many good things along with destructive ones. To know more about the
secret sciences, Why they may have been lost? Why do ancient temples still
hold such a collective sway in the conscience of the people? Why the times of
Chandragupta Maurya and Chanakya may
have been our last shot at knowing the ancient sciences? read “The Indus Challenge”, a historical fiction coming soon to bookstores near
you and available for pre-order on
Amazon.in.